Retention of Glycoprotein Ib/IX Receptors on External Surfaces of Thrombin-Activated Platelets
نویسندگان
چکیده
The present study has evaluated the hypothesis stating that glycoprotein (GP) Ib/lX, the receptor for von Willebrand factor (vWF), is downregulated and cleared from exposed surfaces to channels of the open canalicular system (OCS) on platelets activated by thrombin in suspension. Cryosections of resting and thrombin-activated platelets fixed at intervals of 1 to 30 minutes after stimulation by thrombin and stained with antiglycocalicin antibody and protein A gold showed no decrease in the density of GPlb/lX receptors on the platelet surface or increase on linings of the OCS at any interval after
منابع مشابه
Retention of glycoprotein Ib/IX receptors on external surfaces of thrombin-activated platelets in suspension.
The present study has evaluated the hypothesis stating that glycoprotein (GP) Ib/IX, the receptor for von Willebrand factor (vWF), is downregulated and cleared from exposed surfaces to channels of the open canalicular system (OCS) on platelets activated by thrombin in suspension. Cryosections of resting and thrombin-activated platelets fixed at intervals of 1 to 30 minutes after stimulation by ...
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